Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1191282..1191939 Replicon chromosome
Accession NZ_CP113789
Organism Klebsiella variicola subsp. tropica strain BSK_177V2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OUI59_RS05775 Protein ID WP_002916310.1
Coordinates 1191282..1191692 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag OUI59_RS05780 Protein ID WP_043520925.1
Coordinates 1191673..1191939 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUI59_RS05755 (OUI59_05755) 1187282..1189015 - 1734 WP_074387616.1 single-stranded-DNA-specific exonuclease RecJ -
OUI59_RS05760 (OUI59_05760) 1189021..1189734 - 714 WP_061153358.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OUI59_RS05765 (OUI59_05765) 1189757..1190653 - 897 WP_268657690.1 site-specific tyrosine recombinase XerD -
OUI59_RS05770 (OUI59_05770) 1190754..1191275 + 522 WP_008806427.1 flavodoxin FldB -
OUI59_RS05775 (OUI59_05775) 1191282..1191692 - 411 WP_002916310.1 protein YgfX Toxin
OUI59_RS05780 (OUI59_05780) 1191673..1191939 - 267 WP_043520925.1 FAD assembly factor SdhE Antitoxin
OUI59_RS05785 (OUI59_05785) 1192185..1193168 + 984 WP_100631278.1 tRNA-modifying protein YgfZ -
OUI59_RS05790 (OUI59_05790) 1193346..1194005 - 660 WP_061153356.1 hemolysin III family protein -
OUI59_RS05795 (OUI59_05795) 1194169..1194480 - 312 WP_074387613.1 N(4)-acetylcytidine aminohydrolase -
OUI59_RS05800 (OUI59_05800) 1194531..1195259 + 729 WP_061156320.1 MurR/RpiR family transcriptional regulator -
OUI59_RS05805 (OUI59_05805) 1195379..1196812 + 1434 WP_074387612.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T266044 WP_002916310.1 NZ_CP113789:c1191692-1191282 [Klebsiella variicola subsp. tropica]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.01 Da        Isoelectric Point: 5.1116

>AT266044 WP_043520925.1 NZ_CP113789:c1191939-1191673 [Klebsiella variicola subsp. tropica]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDTDKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure

References