Detailed information of TA system TA026604

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 845236..845713
• Replicon: chromosome
• Accession: NC_017338
• Organism: Staphylococcus aureus subsp. aureus JKD6159

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: SAA6159_RS04000
• Protein ID: WP_000052076.1
• Coordinates: 845236..845424 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: SAA6159_RS04005
• Protein ID: WP_001059691.1
• Coordinates: 845453..845713 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAA6159_RS03970	841229..841750	+	522	WP_000824463.1	hypothetical protein	-
SAA6159_RS03975	842091..842777	+	687	WP_014532746.1	thermonuclease family protein	-
SAA6159_RS03980	843134..843334	+	201	WP_001059082.1	cold-shock protein	-
SAA6159_RS03985	843828..844046	-	219	WP_000005876.1	hypothetical protein	-
SAA6159_RS03990	844108..844392	-	285	WP_001004404.1	hypothetical protein	-
SAA6159_RS03995	844479..845048	-	570	WP_001106649.1	hypothetical protein	-
SAA6159_RS04000	845236..845424	-	189	WP_000052076.1	hypothetical protein	Toxin
SAA6159_RS04005	845453..845713	-	261	WP_001059691.1	hypothetical protein	Antitoxin
SAA6159_RS04010	846054..846257	+	204	WP_000145162.1	sterile alpha motif-like domain-containing protein	-
SAA6159_RS04015	846254..846490	-	237	WP_000368687.1	hypothetical protein	-
SAA6159_RS04020	846715..847296	+	582	WP_001140693.1	phosphoglycerate mutase family protein	-
SAA6159_RS04025	847369..847986	-	618	WP_000255556.1	LysE/ArgO family amino acid transporter	-
SAA6159_RS04030	848141..848635	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
SAA6159_RS04035	849034..849456	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
SAA6159_RS04040	849604..850320	+	717	WP_000150014.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T26604 WP_000052076.1 NC_017338:c845424-845236 [Staphylococcus aureus subsp. aureus JKD6159]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T26604 NC_017338:c845424-845236 [Staphylococcus aureus subsp. aureus JKD6159]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9928.03 Da
• Isoelectric Point: 4.0624

>AT26604 WP_001059691.1 NC_017338:c845713-845453 [Staphylococcus aureus subsp. aureus JKD6159]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFTG

Nucleotide

• Length: 261 bp

>AT26604 NC_017338:c845713-845453 [Staphylococcus aureus subsp. aureus JKD6159]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTACAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18