266037

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2468502..2469122 Replicon chromosome
Accession NZ_CP113784
Organism Citrobacter freundii strain CFSAN077772

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OW080_RS11615 Protein ID WP_002892050.1
Coordinates 2468502..2468720 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag OW080_RS11620 Protein ID WP_003021733.1
Coordinates 2468748..2469122 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OW080_RS11580 (2463735) 2463735..2464364 + 630 WP_032936969.1 membrane protein -
OW080_RS11585 (2464429) 2464429..2464782 + 354 WP_003831033.1 DUF1428 family protein -
OW080_RS11590 (2464834) 2464834..2466387 - 1554 WP_048241431.1 EAL domain-containing protein -
OW080_RS11595 (2466576) 2466576..2466836 + 261 WP_003835926.1 type B 50S ribosomal protein L31 -
OW080_RS11600 (2466838) 2466838..2466978 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
OW080_RS11605 (2467057) 2467057..2467527 - 471 WP_003021724.1 YlaC family protein -
OW080_RS11610 (2467644) 2467644..2468195 - 552 WP_032936967.1 maltose O-acetyltransferase -
OW080_RS11615 (2468502) 2468502..2468720 - 219 WP_002892050.1 HHA domain-containing protein Toxin
OW080_RS11620 (2468748) 2468748..2469122 - 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
OW080_RS11625 (2469611) 2469611..2472760 - 3150 WP_003021736.1 efflux RND transporter permease AcrB -
OW080_RS11630 (2472783) 2472783..2473976 - 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T266037 WP_002892050.1 NZ_CP113784:c2468720-2468502 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT266037 WP_003021733.1 NZ_CP113784:c2469122-2468748 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References