266036

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 2201741..2202420 Replicon chromosome
Accession NZ_CP113784
Organism Citrobacter freundii strain CFSAN077772

Toxin (Protein)


Gene name ykfI Uniprot ID A0A1B7JLK7
Locus tag OW080_RS10370 Protein ID WP_003031349.1
Coordinates 2201741..2202082 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID A0A1B7JLJ2
Locus tag OW080_RS10375 Protein ID WP_003031347.1
Coordinates 2202103..2202420 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OW080_RS10345 (2197485) 2197485..2198216 + 732 WP_016149623.1 winged helix-turn-helix domain-containing protein -
OW080_RS10350 (2198191) 2198191..2198664 + 474 WP_003838775.1 hypothetical protein -
OW080_RS10355 (2199006) 2199006..2200454 + 1449 WP_016149624.1 EAL domain-containing protein -
OW080_RS10360 (2200647) 2200647..2201111 + 465 WP_003843778.1 isoprenylcysteine carboxylmethyltransferase family protein -
OW080_RS10370 (2201741) 2201741..2202082 - 342 WP_003031349.1 type IV toxin-antitoxin system toxin YkfI Toxin
OW080_RS10375 (2202103) 2202103..2202420 - 318 WP_003031347.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OW080_RS10380 (2202438) 2202438..2202659 - 222 WP_003031346.1 DUF987 domain-containing protein -
OW080_RS10385 (2202668) 2202668..2203144 - 477 WP_003031345.1 RadC family protein -
OW080_RS10390 (2203160) 2203160..2203621 - 462 WP_003031344.1 antirestriction protein -
OW080_RS10395 (2204330) 2204330..2206327 + 1998 WP_032939120.1 choline BCCT transporter BetT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12921.01 Da        Isoelectric Point: 9.6543

>T266036 WP_003031349.1 NZ_CP113784:c2202082-2201741 [Citrobacter freundii]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12094.74 Da        Isoelectric Point: 7.0370

>AT266036 WP_003031347.1 NZ_CP113784:c2202420-2202103 [Citrobacter freundii]
MSKITWGLQRDITPRLGARLVQEGNRLHYLADRASMTGKFSDIEYRKLDETFPHFIRQMESMLTTGELSTHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JLK7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JLJ2

References