Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1766728..1767244 Replicon chromosome
Accession NZ_CP113784
Organism Citrobacter freundii strain CFSAN077772

Toxin (Protein)


Gene name relE Uniprot ID A0A0J1MTE6
Locus tag OW080_RS08380 Protein ID WP_016149473.1
Coordinates 1766960..1767244 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag OW080_RS08375 Protein ID WP_003839576.1
Coordinates 1766728..1766970 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OW080_RS08355 (1761743) 1761743..1762876 + 1134 WP_048241739.1 amidohydrolase/deacetylase family metallohydrolase -
OW080_RS08360 (1762860) 1762860..1763978 + 1119 WP_003025770.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
OW080_RS08365 (1763975) 1763975..1764715 + 741 WP_003025772.1 KDGP aldolase family protein -
OW080_RS08370 (1764737) 1764737..1766650 + 1914 WP_048241736.1 BglG family transcription antiterminator -
OW080_RS08375 (1766728) 1766728..1766970 + 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OW080_RS08380 (1766960) 1766960..1767244 + 285 WP_016149473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OW080_RS08385 (1767248) 1767248..1767712 - 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OW080_RS08390 (1767819) 1767819..1769957 - 2139 WP_003839582.1 anaerobic ribonucleoside-triphosphate reductase -
OW080_RS08395 (1770335) 1770335..1770919 - 585 WP_003839584.1 fructose PTS transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10878.73 Da        Isoelectric Point: 10.0482

>T266035 WP_016149473.1 NZ_CP113784:1766960-1767244 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT266035 WP_003839576.1 NZ_CP113784:1766728-1766970 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MTE6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References