266034

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1510869..1511535 Replicon chromosome
Accession NZ_CP113784
Organism Citrobacter freundii strain CFSAN077772

Toxin (Protein)


Gene name tad Uniprot ID A0A0J1MRN0
Locus tag OW080_RS07165 Protein ID WP_032938228.1
Coordinates 1510869..1511228 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0J1QJH0
Locus tag OW080_RS07170 Protein ID WP_032938223.1
Coordinates 1511218..1511535 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OW080_RS07155 (1508269) 1508269..1509900 + 1632 WP_032938230.1 Na/Pi cotransporter family protein -
OW080_RS07160 (1509966) 1509966..1510655 - 690 WP_003841421.1 dipeptidase PepE -
OW080_RS07165 (1510869) 1510869..1511228 + 360 WP_032938228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OW080_RS07170 (1511218) 1511218..1511535 + 318 WP_032938223.1 helix-turn-helix transcriptional regulator Antitoxin
OW080_RS07175 (1511675) 1511675..1511836 - 162 WP_003841416.1 phage protein -
OW080_RS07180 (1511907) 1511907..1512080 - 174 WP_032938222.1 hypothetical protein -
OW080_RS07185 (1512212) 1512212..1512568 + 357 WP_032938220.1 hypothetical protein -
OW080_RS07190 (1512618) 1512618..1513430 - 813 WP_048241809.1 shikimate 5-dehydrogenase -
OW080_RS07195 (1513432) 1513432..1514655 - 1224 WP_048241807.1 L-sorbose 1-phosphate reductase -
OW080_RS07200 (1514724) 1514724..1515548 - 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
OW080_RS07205 (1515560) 1515560..1516357 - 798 WP_003841402.1 PTS mannose/fructose/sorbose transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13411.37 Da        Isoelectric Point: 10.3350

>T266034 WP_032938228.1 NZ_CP113784:1510869-1511228 [Citrobacter freundii]
MTKPLYWVGHARKDLQGMPEHVRDTFGFALWLAQQGKQHSQTKSLKGFGGAGVLEVVEDHHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11451.29 Da        Isoelectric Point: 6.9796

>AT266034 WP_032938223.1 NZ_CP113784:1511218-1511535 [Citrobacter freundii]
MSHEVEASSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGEEGNMSGKLKVKFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MRN0

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1QJH0

References