266032

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 917621..918252 Replicon chromosome
Accession NZ_CP113784
Organism Citrobacter freundii strain CFSAN077772

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag OW080_RS04380 Protein ID WP_003837806.1
Coordinates 917977..918252 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag OW080_RS04375 Protein ID WP_003837808.1
Coordinates 917621..917980 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OW080_RS04345 (912719) 912719..913384 + 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -
OW080_RS04350 (913457) 913457..914014 + 558 WP_003837816.1 DcrB family lipoprotein -
OW080_RS04355 (914018) 914018..915235 - 1218 WP_048217067.1 MFS transporter -
OW080_RS04360 (915369) 915369..916418 + 1050 WP_003023393.1 AI-2E family transporter -
OW080_RS04365 (916481) 916481..917059 + 579 WP_003023390.1 4'-phosphopantetheinyl transferase AcpT -
OW080_RS04370 (917109) 917109..917510 + 402 WP_032937232.1 nickel-responsive transcriptional regulator NikR -
OW080_RS04375 (917621) 917621..917980 - 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OW080_RS04380 (917977) 917977..918252 - 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
OW080_RS04385 (918330) 918330..919454 - 1125 WP_003837801.1 ABC transporter permease -
OW080_RS04390 (919454) 919454..922201 - 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T266032 WP_003837806.1 NZ_CP113784:c918252-917977 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT266032 WP_003837808.1 NZ_CP113784:c917980-917621 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References