Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 491911..492590 Replicon chromosome
Accession NZ_CP113784
Organism Citrobacter freundii strain CFSAN077772

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag OW080_RS02250 Protein ID WP_063200007.1
Coordinates 491911..492252 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID -
Locus tag OW080_RS02255 Protein ID WP_063200004.1
Coordinates 492273..492590 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OW080_RS02230 (487954) 487954..489003 + 1050 WP_048242018.1 YncE family protein -
OW080_RS02235 (489014) 489014..491011 + 1998 WP_032937340.1 TonB-dependent receptor -
OW080_RS02240 (491042) 491042..491548 - 507 WP_016151005.1 G/U mismatch-specific DNA glycosylase -
OW080_RS02250 (491911) 491911..492252 - 342 WP_063200007.1 TA system toxin CbtA family protein Toxin
OW080_RS02255 (492273) 492273..492590 - 318 WP_063200004.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OW080_RS02260 (492609) 492609..492830 - 222 WP_001618789.1 DUF987 domain-containing protein -
OW080_RS02265 (492839) 492839..493315 - 477 WP_063199998.1 RadC family protein -
OW080_RS02270 (493331) 493331..493789 - 459 WP_063199995.1 antirestriction protein -
OW080_RS02275 (493891) 493891..494130 - 240 WP_063255812.1 DUF905 domain-containing protein -
OW080_RS02280 (494207) 494207..494674 - 468 WP_001547765.1 protein YkfB -
OW080_RS02285 (494703) 494703..495140 - 438 WP_063255811.1 lipoprotein YafY -
OW080_RS02290 (495140) 495140..495376 - 237 WP_063255810.1 protein YpjK -
OW080_RS02295 (495413) 495413..496114 - 702 WP_063255809.1 WYL domain-containing protein -
OW080_RS02300 (496331) 496331..497152 - 822 WP_063255808.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13107.16 Da        Isoelectric Point: 9.6241

>T266030 WP_063200007.1 NZ_CP113784:c492252-491911 [Citrobacter freundii]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKEF
SWQEQSPYLRAVDILRARQVTGLLRQSRKNSVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11937.49 Da        Isoelectric Point: 6.9464

>AT266030 WP_063200004.1 NZ_CP113784:c492590-492273 [Citrobacter freundii]
MSNITWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDAECRKLDETFPHFIRQMESMLTTGEVSPQHAHCVTLYH
NDFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References