266029

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 333528..334182 Replicon chromosome
Accession NZ_CP113784
Organism Citrobacter freundii strain CFSAN077772

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag OW080_RS01485 Protein ID WP_003026936.1
Coordinates 333528..333935 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag OW080_RS01490 Protein ID WP_003026938.1
Coordinates 333916..334182 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OW080_RS01465 (329476) 329476..331209 - 1734 WP_032937435.1 single-stranded-DNA-specific exonuclease RecJ -
OW080_RS01470 (331215) 331215..331928 - 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OW080_RS01475 (331952) 331952..332848 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
OW080_RS01480 (332962) 332962..333483 + 522 WP_003026933.1 flavodoxin FldB -
OW080_RS01485 (333528) 333528..333935 - 408 WP_003026936.1 protein YgfX Toxin
OW080_RS01490 (333916) 333916..334182 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
OW080_RS01495 (334439) 334439..335419 + 981 WP_003838269.1 tRNA-modifying protein YgfZ -
OW080_RS01500 (335513) 335513..336172 - 660 WP_003838267.1 hemolysin III family protein -
OW080_RS01505 (336335) 336335..336646 - 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
OW080_RS01510 (336699) 336699..337427 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
OW080_RS01515 (337548) 337548..338981 + 1434 WP_032937433.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T266029 WP_003026936.1 NZ_CP113784:c333935-333528 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT266029 WP_003026938.1 NZ_CP113784:c334182-333916 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References