Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4159176..4160753 Replicon chromosome
Accession NZ_CP113783
Organism Pseudoxanthomonas sp. SE1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OY559_RS19435 Protein ID WP_277727937.1
Coordinates 4159440..4160753 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OY559_RS19430 Protein ID WP_277727935.1
Coordinates 4159176..4159436 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OY559_RS19420 (OY559_19430) 4154534..4155166 - 633 WP_277727933.1 tetratricopeptide repeat protein -
OY559_RS19425 (OY559_19435) 4155322..4159032 + 3711 WP_277727934.1 indolepyruvate ferredoxin oxidoreductase family protein -
OY559_RS19430 (OY559_19440) 4159176..4159436 + 261 WP_277727935.1 helix-turn-helix domain-containing protein Antitoxin
OY559_RS19435 (OY559_19445) 4159440..4160753 + 1314 WP_277727937.1 type II toxin-antitoxin system HipA family toxin Toxin
OY559_RS19440 (OY559_19450) 4160862..4161647 - 786 WP_277727938.1 hypothetical protein -
OY559_RS19445 (OY559_19455) 4161909..4162631 + 723 WP_277727939.1 iron-containing redox enzyme family protein -
OY559_RS19450 (OY559_19460) 4162628..4163059 + 432 WP_277727940.1 VOC family protein -
OY559_RS19455 (OY559_19465) 4163063..4163662 - 600 WP_277727941.1 DUF938 domain-containing protein -
OY559_RS19460 (OY559_19470) 4163662..4164495 - 834 WP_277727942.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4152504..4160753 8249


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-67)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48674.75 Da        Isoelectric Point: 7.8271

>T266028 WP_277727937.1 NZ_CP113783:4159440-4160753 [Pseudoxanthomonas sp. SE1]
MGELRIWMNGVEAATWQDAQPTRLTYVSSWLASSLARPLSLSLPLLPEGTSHRGDVVENYFDNLLPDSTNIRARLRNRFA
VPSNSTFALLEQIGRDCVGAIQLLPANTLPDEVRTIQARALDEAGVARLLRGVASPLLPGNHDGDSFRLSLAGAQEKTAL
LFHNGQWCVPLGSTPSTHIFKLPLGRVGNMRADMASSVENEWLCMQLLRAFGLPVANTSIGRFEELRVLVVERFDRRLSG
DGSWWIRLPQEDLCQVFGLPSSRKYENDGGPGVVQIMDLLRQSIEPRDREIFFKTQILFWLLAATDGHAKNFSLHIEPQG
RFRLTPLYDVLSVYPILGHGPQQLDPHEAVLAMSVVGKNKHRKLLNVRRRHWNETARACGVRHGAEPWLEDLLGRIEPAI
TSVAAQLPTDFPVEVAHAIFDGLRRAGDRLRGMAPGH

Download         Length: 1314 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9445.06 Da        Isoelectric Point: 10.0872

>AT266028 WP_277727935.1 NZ_CP113783:4159176-4159436 [Pseudoxanthomonas sp. SE1]
MTAAQYPIQTPQQLAPLLRALRKKQGLTQADLAEQLGITRQAVTALEARPEAATFERLMKVWAVLGLQVLLAPRTPPSPS
LDAVEW

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References