Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1333301..1333823 Replicon chromosome
Accession NZ_CP113782
Organism Rothia kristinae strain ND-2018N

Toxin (Protein)


Gene name relE Uniprot ID A0A147E9L9
Locus tag OU799_RS06105 Protein ID WP_058731840.1
Coordinates 1333563..1333823 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7T3F706
Locus tag OU799_RS06100 Protein ID WP_058731839.1
Coordinates 1333301..1333561 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU799_RS06080 (OU799_06085) 1328372..1328938 - 567 WP_058731452.1 HIT domain-containing protein -
OU799_RS06085 (OU799_06090) 1329051..1329557 + 507 WP_100463620.1 FBP domain-containing protein -
OU799_RS06090 (OU799_06095) 1329636..1331651 - 2016 WP_224799475.1 threonine--tRNA ligase -
OU799_RS06095 (OU799_06100) 1331802..1333088 - 1287 WP_279751909.1 SLC13 family permease -
OU799_RS06100 (OU799_06105) 1333301..1333561 + 261 WP_058731839.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OU799_RS06105 (OU799_06110) 1333563..1333823 + 261 WP_058731840.1 Txe/YoeB family addiction module toxin Toxin
OU799_RS06110 (OU799_06115) 1333851..1337297 - 3447 WP_279751910.1 PHP domain-containing protein -
OU799_RS06115 (OU799_06120) 1337330..1338070 - 741 WP_058731290.1 3-keto-5-aminohexanoate cleavage protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10533.96 Da        Isoelectric Point: 9.5181

>T266025 WP_058731840.1 NZ_CP113782:1333563-1333823 [Rothia kristinae]
MLLTWDPDAWEDYLWWQRQDRAVLRRINTLIRDIQRHGNEGIGKPEPLRHDFAGYWSRRITAEHRLVYRLTDRQVLIAAC
RYHYGQ

Download         Length: 261 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9690.84 Da        Isoelectric Point: 4.7091

>AT266025 WP_058731839.1 NZ_CP113782:1333301-1333561 [Rothia kristinae]
VKTMTYTESRARYAEVLDGVVQDREEVVITRSGHDPVVILSLAEYESLKETAHLLRSPSNARRLLDAMQRLEAGEGERHE
LVDPDA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A147E9L9

Antitoxin

Source ID Structure
AlphaFold DB A0A7T3F706

References