Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4326838..4327619 Replicon chromosome
Accession NZ_CP113541
Organism Salmonella enterica strain CHC

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag OXV05_RS20915 Protein ID WP_000626099.1
Coordinates 4326838..4327329 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag OXV05_RS20920 Protein ID WP_001110452.1
Coordinates 4327326..4327619 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV05_RS20880 (4322833) 4322833..4323408 + 576 WP_001188509.1 transcriptional regulator -
OXV05_RS20890 (4323679) 4323679..4323756 - 78 Protein_4085 helix-turn-helix domain-containing protein -
OXV05_RS20895 (4323847) 4323847..4324179 - 333 WP_001165471.1 MerR family transcriptional regulator -
OXV05_RS20900 (4324251) 4324251..4324628 + 378 WP_000916345.1 EthD family reductase -
OXV05_RS20905 (4325661) 4325661..4325735 + 75 Protein_4088 porin family protein -
OXV05_RS20910 (4325838) 4325838..4326590 + 753 WP_000842434.1 non-specific acid phosphatase -
OXV05_RS20915 (4326838) 4326838..4327329 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
OXV05_RS20920 (4327326) 4327326..4327619 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
OXV05_RS20925 (4327936) 4327936..4328157 + 222 WP_001576552.1 hypothetical protein -
OXV05_RS20930 (4328422) 4328422..4329297 + 876 WP_000921674.1 AraC family transcriptional regulator -
OXV05_RS20935 (4329294) 4329294..4329581 + 288 WP_001269916.1 transcriptional regulator RtsB -
OXV05_RS20940 (4329604) 4329604..4329819 + 216 WP_001595136.1 hypothetical protein -
OXV05_RS20945 (4329827) 4329827..4330096 + 270 WP_010989096.1 hypothetical protein -
OXV05_RS20950 (4330390) 4330390..4331295 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T266022 WP_000626099.1 NZ_CP113541:c4327329-4326838 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT266022 WP_001110452.1 NZ_CP113541:c4327619-4327326 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References