Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3433469..3434089 Replicon chromosome
Accession NZ_CP113541
Organism Salmonella enterica strain CHC

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OXV05_RS16735 Protein ID WP_001280991.1
Coordinates 3433871..3434089 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OXV05_RS16730 Protein ID WP_000344807.1
Coordinates 3433469..3433843 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV05_RS16720 (3428608) 3428608..3429801 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OXV05_RS16725 (3429824) 3429824..3432973 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
OXV05_RS16730 (3433469) 3433469..3433843 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OXV05_RS16735 (3433871) 3433871..3434089 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OXV05_RS16740 (3434268) 3434268..3434819 + 552 WP_001278792.1 maltose O-acetyltransferase -
OXV05_RS16745 (3434936) 3434936..3435406 + 471 WP_000136181.1 YlaC family protein -
OXV05_RS16750 (3435462) 3435462..3435602 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OXV05_RS16755 (3435608) 3435608..3435868 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OXV05_RS16760 (3436093) 3436093..3437643 + 1551 WP_268650649.1 EAL domain-containing protein -
OXV05_RS16770 (3437874) 3437874..3438263 + 390 WP_000961285.1 MGMT family protein -
OXV05_RS16775 (3438296) 3438296..3438865 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T266017 WP_001280991.1 NZ_CP113541:3433871-3434089 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT266017 WP_000344807.1 NZ_CP113541:3433469-3433843 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References