266003

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4213574..4214355 Replicon chromosome
Accession NZ_CP113540
Organism Salmonella enterica strain CYX

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag OXV10_RS20700 Protein ID WP_000626100.1
Coordinates 4213574..4214065 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag OXV10_RS20705 Protein ID WP_001110452.1
Coordinates 4214062..4214355 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV10_RS20665 (4209034) 4209034..4209381 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
OXV10_RS20670 (4209357) 4209357..4211060 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
OXV10_RS20675 (4211097) 4211097..4211672 + 576 WP_001188509.1 transcriptional regulator -
OXV10_RS20685 (4211943) 4211943..4212017 - 75 Protein_4043 helix-turn-helix domain-containing protein -
OXV10_RS20690 (4212397) 4212397..4212474 + 78 Protein_4044 porin family protein -
OXV10_RS20695 (4212574) 4212574..4213326 + 753 WP_000842433.1 non-specific acid phosphatase -
OXV10_RS20700 (4213574) 4213574..4214065 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
OXV10_RS20705 (4214062) 4214062..4214355 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
OXV10_RS20710 (4214672) 4214672..4214893 + 222 WP_001576552.1 hypothetical protein -
OXV10_RS20715 (4215159) 4215159..4216034 + 876 WP_000921676.1 AraC family transcriptional regulator -
OXV10_RS20720 (4216031) 4216031..4216318 + 288 WP_001541332.1 transcriptional regulator RtsB -
OXV10_RS20725 (4216311) 4216311..4216619 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
OXV10_RS20730 (4216618) 4216618..4216866 + 249 Protein_4052 Ig-like domain-containing protein -
OXV10_RS20735 (4216978) 4216978..4217109 + 132 Protein_4053 hypothetical protein -
OXV10_RS20740 (4217403) 4217403..4218308 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T266003 WP_000626100.1 NZ_CP113540:c4214065-4213574 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT266003 WP_001110452.1 NZ_CP113540:c4214355-4214062 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References