266001

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4065553..4066103 Replicon chromosome
Accession NZ_CP113540
Organism Salmonella enterica strain CYX

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag OXV10_RS19915 Protein ID WP_001199743.1
Coordinates 4065553..4065861 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag OXV10_RS19920 Protein ID WP_001118105.1
Coordinates 4065864..4066103 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV10_RS19895 (4062127) 4062127..4062867 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
OXV10_RS19900 (4062989) 4062989..4063519 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
OXV10_RS19905 (4063842) 4063842..4064975 + 1134 Protein_3892 IS3 family transposase -
OXV10_RS19910 (4065007) 4065007..4065147 - 141 Protein_3893 Arm DNA-binding domain-containing protein -
OXV10_RS19915 (4065553) 4065553..4065861 - 309 WP_001199743.1 CcdB family protein Toxin
OXV10_RS19920 (4065864) 4065864..4066103 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
OXV10_RS19925 (4066212) 4066212..4066460 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
OXV10_RS19930 (4066651) 4066651..4067082 - 432 Protein_3897 helix-turn-helix domain-containing protein -
OXV10_RS19940 (4067839) 4067839..4068858 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
OXV10_RS19945 (4068886) 4068886..4069416 - 531 WP_000896758.1 gluconokinase -
OXV10_RS19950 (4069633) 4069633..4070664 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4063934..4067037 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T266001 WP_001199743.1 NZ_CP113540:c4065861-4065553 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT266001 WP_001118105.1 NZ_CP113540:c4066103-4065864 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References