Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4021293..4021869 Replicon chromosome
Accession NZ_CP113540
Organism Salmonella enterica strain CYX

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag OXV10_RS19700 Protein ID WP_001131963.1
Coordinates 4021582..4021869 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag OXV10_RS19695 Protein ID WP_000063142.1
Coordinates 4021293..4021595 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV10_RS19680 (4017803) 4017803..4019953 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
OXV10_RS19685 (4020048) 4020048..4020251 + 204 WP_000460616.1 YbdD/YjiX family protein -
OXV10_RS19690 (4020262) 4020262..4021218 + 957 WP_000187843.1 GTPase -
OXV10_RS19695 (4021293) 4021293..4021595 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
OXV10_RS19700 (4021582) 4021582..4021869 - 288 WP_001131963.1 BrnT family toxin Toxin
OXV10_RS19705 (4022286) 4022286..4023542 + 1257 Protein_3852 NERD domain-containing protein/DEAD/DEAH box helicase -
OXV10_RS19710 (4023536) 4023536..4023715 + 180 Protein_3853 DNA methyltransferase -
OXV10_RS19715 (4023705) 4023705..4025009 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T266000 WP_001131963.1 NZ_CP113540:c4021869-4021582 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT266000 WP_000063142.1 NZ_CP113540:c4021595-4021293 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References