265997

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3445763..3446383 Replicon chromosome
Accession NZ_CP113540
Organism Salmonella enterica strain CYX

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OXV10_RS17050 Protein ID WP_001280991.1
Coordinates 3446165..3446383 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OXV10_RS17045 Protein ID WP_000344807.1
Coordinates 3445763..3446137 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV10_RS17035 (3440902) 3440902..3442095 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OXV10_RS17040 (3442118) 3442118..3445267 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
OXV10_RS17045 (3445763) 3445763..3446137 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OXV10_RS17050 (3446165) 3446165..3446383 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OXV10_RS17055 (3446562) 3446562..3447113 + 552 WP_001278793.1 maltose O-acetyltransferase -
OXV10_RS17060 (3447231) 3447231..3447701 + 471 WP_000136183.1 YlaC family protein -
OXV10_RS17065 (3447757) 3447757..3447897 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OXV10_RS17070 (3447903) 3447903..3448163 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OXV10_RS17075 (3448388) 3448388..3449938 + 1551 WP_000213140.1 EAL domain-containing protein -
OXV10_RS17085 (3450169) 3450169..3450558 + 390 WP_000961287.1 MGMT family protein -
OXV10_RS17090 (3450591) 3450591..3451160 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T265997 WP_001280991.1 NZ_CP113540:3446165-3446383 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT265997 WP_000344807.1 NZ_CP113540:3445763-3446137 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References