Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4225587..4226368 Replicon chromosome
Accession NZ_CP113539
Organism Salmonella enterica strain FFL

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I1HVL4
Locus tag OXV09_RS20520 Protein ID WP_023255089.1
Coordinates 4225587..4226078 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag OXV09_RS20525 Protein ID WP_001271379.1
Coordinates 4226075..4226368 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV09_RS20495 (4222468) 4222468..4223298 - 831 WP_079948288.1 fimbria/pilus periplasmic chaperone -
OXV09_RS20500 (4223500) 4223500..4223712 - 213 WP_001293880.1 PapB/FocB family fimbrial expression transcriptional regulator -
OXV09_RS20505 (4224337) 4224337..4224480 + 144 Protein_4012 transposase -
OXV09_RS20510 (4224497) 4224497..4224843 + 347 Protein_4013 Rpn family recombination-promoting nuclease/putative transposase -
OXV09_RS20515 (4225124) 4225124..4225372 - 249 Protein_4014 IS481 family transposase -
OXV09_RS20520 (4225587) 4225587..4226078 - 492 WP_023255089.1 GNAT family N-acetyltransferase Toxin
OXV09_RS20525 (4226075) 4226075..4226368 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
OXV09_RS20530 (4226686) 4226686..4226908 + 223 Protein_4017 hypothetical protein -
OXV09_RS20535 (4227174) 4227174..4228049 + 876 WP_000921674.1 AraC family transcriptional regulator -
OXV09_RS20540 (4228046) 4228046..4228333 + 288 WP_001269916.1 transcriptional regulator RtsB -
OXV09_RS20545 (4228356) 4228356..4228570 + 215 Protein_4020 hypothetical protein -
OXV09_RS20550 (4228578) 4228578..4228721 + 144 Protein_4021 hypothetical protein -
OXV09_RS20555 (4228833) 4228833..4228922 + 90 Protein_4022 hypothetical protein -
OXV09_RS20560 (4229211) 4229211..4230116 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4214980..4228922 13942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17633.45 Da        Isoelectric Point: 7.7297

>T265983 WP_023255089.1 NZ_CP113539:c4226078-4225587 [Salmonella enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT265983 WP_001271379.1 NZ_CP113539:c4226368-4226075 [Salmonella enterica]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I1HVL4

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References