Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3410421..3411041 Replicon chromosome
Accession NZ_CP113539
Organism Salmonella enterica strain FFL

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OXV09_RS16655 Protein ID WP_001280991.1
Coordinates 3410823..3411041 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OXV09_RS16650 Protein ID WP_000344807.1
Coordinates 3410421..3410795 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV09_RS16640 (3405560) 3405560..3406753 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OXV09_RS16645 (3406776) 3406776..3409925 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
OXV09_RS16650 (3410421) 3410421..3410795 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OXV09_RS16655 (3410823) 3410823..3411041 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OXV09_RS16660 (3411220) 3411220..3411771 + 552 WP_023243161.1 maltose O-acetyltransferase -
OXV09_RS16665 (3411889) 3411889..3412359 + 471 WP_000136183.1 YlaC family protein -
OXV09_RS16670 (3412415) 3412415..3412555 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OXV09_RS16675 (3412561) 3412561..3412821 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OXV09_RS16680 (3413046) 3413046..3414596 + 1551 WP_000213145.1 EAL domain-containing protein -
OXV09_RS16690 (3414827) 3414827..3415216 + 390 WP_000961285.1 MGMT family protein -
OXV09_RS16695 (3415249) 3415249..3415818 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T265978 WP_001280991.1 NZ_CP113539:3410823-3411041 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT265978 WP_000344807.1 NZ_CP113539:3410421-3410795 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References