Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4333575..4334356 Replicon chromosome
Accession NZ_CP113538
Organism Salmonella enterica strain XSK

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag OXV06_RS20975 Protein ID WP_000626099.1
Coordinates 4333575..4334066 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag OXV06_RS20980 Protein ID WP_001110452.1
Coordinates 4334063..4334356 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV06_RS20940 (4329570) 4329570..4330145 + 576 WP_001188509.1 transcriptional regulator -
OXV06_RS20950 (4330416) 4330416..4330493 - 78 Protein_4093 helix-turn-helix domain-containing protein -
OXV06_RS20955 (4330584) 4330584..4330916 - 333 WP_001165471.1 MerR family transcriptional regulator -
OXV06_RS20960 (4330988) 4330988..4331365 + 378 WP_000916345.1 EthD family reductase -
OXV06_RS20965 (4332398) 4332398..4332472 + 75 Protein_4096 porin family protein -
OXV06_RS20970 (4332575) 4332575..4333327 + 753 WP_000842434.1 non-specific acid phosphatase -
OXV06_RS20975 (4333575) 4333575..4334066 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
OXV06_RS20980 (4334063) 4334063..4334356 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
OXV06_RS20985 (4334673) 4334673..4334894 + 222 WP_001576552.1 hypothetical protein -
OXV06_RS20990 (4335159) 4335159..4336034 + 876 WP_000921674.1 AraC family transcriptional regulator -
OXV06_RS20995 (4336031) 4336031..4336318 + 288 WP_001269916.1 transcriptional regulator RtsB -
OXV06_RS21000 (4336341) 4336341..4336556 + 216 WP_001595136.1 hypothetical protein -
OXV06_RS21005 (4336564) 4336564..4336833 + 270 WP_010989096.1 hypothetical protein -
OXV06_RS21010 (4337127) 4337127..4338032 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T265966 WP_000626099.1 NZ_CP113538:c4334066-4333575 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT265966 WP_001110452.1 NZ_CP113538:c4334356-4334063 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References