Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3433849..3434469 Replicon chromosome
Accession NZ_CP113538
Organism Salmonella enterica strain XSK

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OXV06_RS16745 Protein ID WP_001280991.1
Coordinates 3434251..3434469 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OXV06_RS16740 Protein ID WP_000344807.1
Coordinates 3433849..3434223 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV06_RS16730 (3428988) 3428988..3430181 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OXV06_RS16735 (3430204) 3430204..3433353 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
OXV06_RS16740 (3433849) 3433849..3434223 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OXV06_RS16745 (3434251) 3434251..3434469 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OXV06_RS16750 (3434648) 3434648..3435199 + 552 WP_001278792.1 maltose O-acetyltransferase -
OXV06_RS16755 (3435316) 3435316..3435786 + 471 WP_000136181.1 YlaC family protein -
OXV06_RS16760 (3435842) 3435842..3435982 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OXV06_RS16765 (3435988) 3435988..3436248 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OXV06_RS16770 (3436473) 3436473..3438023 + 1551 WP_000213139.1 EAL domain-containing protein -
OXV06_RS16780 (3438254) 3438254..3438643 + 390 WP_000961285.1 MGMT family protein -
OXV06_RS16785 (3438676) 3438676..3439245 - 570 WP_268650663.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T265961 WP_001280991.1 NZ_CP113538:3434251-3434469 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT265961 WP_000344807.1 NZ_CP113538:3433849-3434223 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References