Detailed information of TA system TA026596

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2159138..2159667
• Replicon: chromosome
• Accession: NC_017337
• Organism: Staphylococcus aureus subsp. aureus ED133

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: SAOV_RS11095
• Protein ID: WP_000621175.1
• Coordinates: 2159138..2159500 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: SAOV_RS11100
• Protein ID: WP_000948331.1
• Coordinates: 2159497..2159667 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAOV_RS11070	2156116..2156886	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
SAOV_RS11075	2156861..2157340	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
SAOV_RS11080	2157342..2157668	-	327	WP_001052491.1	anti-sigma factor antagonist	-
SAOV_RS11085	2157787..2158788	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
SAOV_RS11095	2159138..2159500	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SAOV_RS11100	2159497..2159667	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
SAOV_RS11105	2159752..2160900	-	1149	WP_001281150.1	alanine racemase	-
SAOV_RS11110	2160966..2161325	-	360	WP_000581198.1	holo-ACP synthase	-
SAOV_RS11115	2161329..2161820	-	492	WP_001286982.1	PH domain-containing protein	-
SAOV_RS11120	2161813..2163390	-	1578	WP_001294643.1	PH domain-containing protein	-
SAOV_RS11125	2163383..2163862	-	480	WP_001287084.1	hypothetical protein	-
SAOV_RS11130	2164071..2164631	-	561	WP_001092415.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T26596 WP_000621175.1 NC_017337:c2159500-2159138 [Staphylococcus aureus subsp. aureus ED133]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T26596 NC_017337:c2159500-2159138 [Staphylococcus aureus subsp. aureus ED133]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT26596 WP_000948331.1 NC_017337:c2159667-2159497 [Staphylococcus aureus subsp. aureus ED133]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT26596 NC_017337:c2159667-2159497 [Staphylococcus aureus subsp. aureus ED133]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1