Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1940643..1941419 Replicon chromosome
Accession NC_017337
Organism Staphylococcus aureus subsp. aureus ED133

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag SAOV_RS09695 Protein ID WP_000031108.1
Coordinates 1940643..1940795 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag SAOV_RS09700 Protein ID WP_001251219.1
Coordinates 1940820..1941419 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAOV_RS09675 1936652..1937473 + 822 WP_000669385.1 RluA family pseudouridine synthase -
SAOV_RS09680 1937924..1939309 - 1386 WP_000116236.1 class II fumarate hydratase -
SAOV_RS09685 1939505..1939900 - 396 WP_000901023.1 hypothetical protein -
SAOV_RS15460 1940121..1940258 + 138 WP_167884751.1 hypothetical protein -
SAOV_RS09695 1940643..1940795 - 153 WP_000031108.1 hypothetical protein Toxin
SAOV_RS09700 1940820..1941419 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
SAOV_RS09705 1941578..1942048 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
SAOV_RS09710 1942053..1943180 - 1128 WP_000379979.1 tRNA epoxyqueuosine(34) reductase QueG -
SAOV_RS09715 1943331..1944053 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
SAOV_RS09720 1944046..1945503 - 1458 WP_000649892.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T26595 WP_000031108.1 NC_017337:c1940795-1940643 [Staphylococcus aureus subsp. aureus ED133]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T26595 NC_017337:c1940795-1940643 [Staphylococcus aureus subsp. aureus ED133]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT26595 WP_001251219.1 NC_017337:c1941419-1940820 [Staphylococcus aureus subsp. aureus ED133]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT26595 NC_017337:c1941419-1940820 [Staphylococcus aureus subsp. aureus ED133]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCTGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References