Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3345284..3345904 Replicon chromosome
Accession NZ_CP113537
Organism Salmonella enterica strain YZY

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OXV04_RS16130 Protein ID WP_001280991.1
Coordinates 3345686..3345904 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OXV04_RS16125 Protein ID WP_000344807.1
Coordinates 3345284..3345658 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV04_RS16115 (3340423) 3340423..3341616 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OXV04_RS16120 (3341639) 3341639..3344788 + 3150 WP_126524222.1 efflux RND transporter permease AcrB -
OXV04_RS16125 (3345284) 3345284..3345658 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OXV04_RS16130 (3345686) 3345686..3345904 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OXV04_RS16135 (3346083) 3346083..3346634 + 552 WP_001278793.1 maltose O-acetyltransferase -
OXV04_RS16140 (3346752) 3346752..3347222 + 471 WP_126524223.1 YlaC family protein -
OXV04_RS16145 (3347278) 3347278..3347418 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OXV04_RS16150 (3347420) 3347420..3347683 - 264 WP_000801416.1 type B 50S ribosomal protein L31 -
OXV04_RS16155 (3347908) 3347908..3349458 + 1551 WP_126524224.1 EAL domain-containing protein -
OXV04_RS16165 (3349689) 3349689..3350078 + 390 WP_126524225.1 MGMT family protein -
OXV04_RS16170 (3350111) 3350111..3350680 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T265944 WP_001280991.1 NZ_CP113537:3345686-3345904 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT265944 WP_000344807.1 NZ_CP113537:3345284-3345658 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References