Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 213378..214138 Replicon chromosome
Accession NZ_CP113537
Organism Salmonella enterica strain YZY

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag OXV04_RS01005 Protein ID WP_000533909.1
Coordinates 213653..214138 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag OXV04_RS01000 Protein ID WP_000965889.1
Coordinates 213378..213665 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV04_RS00980 (208724) 208724..210052 - 1329 WP_000200570.1 MFS transporter -
OXV04_RS00985 (210240) 210240..211400 - 1161 WP_000107288.1 mandelate racemase/muconate lactonizing enzyme family protein -
OXV04_RS00990 (211506) 211506..212405 + 900 WP_000462482.1 LysR family transcriptional regulator -
OXV04_RS00995 (212542) 212542..213195 - 654 WP_126523757.1 LysE family translocator -
OXV04_RS01000 (213378) 213378..213665 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
OXV04_RS01005 (213653) 213653..214138 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
OXV04_RS01010 (214509) 214509..215048 - 540 WP_126523758.1 copper-binding periplasmic metallochaperone CueP -
OXV04_RS01015 (215221) 215221..215433 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
OXV04_RS01020 (215721) 215721..216011 - 291 WP_000455790.1 HTH-type transcriptional regulator -
OXV04_RS01025 (216450) 216450..217160 + 711 WP_000190524.1 DUF3053 domain-containing protein -
OXV04_RS01030 (217210) 217210..218184 - 975 WP_000804684.1 glyoxylate/hydroxypyruvate reductase GhrB -
OXV04_RS01035 (218403) 218403..219065 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T265935 WP_000533909.1 NZ_CP113537:213653-214138 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT265935 WP_000965889.1 NZ_CP113537:213378-213665 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References