Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4338073..4338854 Replicon chromosome
Accession NZ_CP113536
Organism Salmonella enterica strain ZCX

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag OXV07_RS21180 Protein ID WP_000626099.1
Coordinates 4338073..4338564 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag OXV07_RS21185 Protein ID WP_001110452.1
Coordinates 4338561..4338854 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV07_RS21145 (4334068) 4334068..4334643 + 576 WP_001188509.1 transcriptional regulator -
OXV07_RS21155 (4334914) 4334914..4334991 - 78 Protein_4135 helix-turn-helix domain-containing protein -
OXV07_RS21160 (4335082) 4335082..4335414 - 333 WP_001165471.1 MerR family transcriptional regulator -
OXV07_RS21165 (4335486) 4335486..4335863 + 378 WP_000916345.1 EthD family reductase -
OXV07_RS21170 (4336896) 4336896..4336970 + 75 Protein_4138 porin family protein -
OXV07_RS21175 (4337073) 4337073..4337825 + 753 WP_000842434.1 non-specific acid phosphatase -
OXV07_RS21180 (4338073) 4338073..4338564 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
OXV07_RS21185 (4338561) 4338561..4338854 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
OXV07_RS21190 (4339171) 4339171..4339392 + 222 WP_054175531.1 hypothetical protein -
OXV07_RS21195 (4339657) 4339657..4340532 + 876 WP_000921674.1 AraC family transcriptional regulator -
OXV07_RS21200 (4340529) 4340529..4340816 + 288 WP_001269916.1 transcriptional regulator RtsB -
OXV07_RS21205 (4340839) 4340839..4341054 + 216 WP_001595136.1 hypothetical protein -
OXV07_RS21210 (4341062) 4341062..4341331 + 270 WP_010989096.1 hypothetical protein -
OXV07_RS21215 (4341625) 4341625..4342530 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T265932 WP_000626099.1 NZ_CP113536:c4338564-4338073 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT265932 WP_001110452.1 NZ_CP113536:c4338854-4338561 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References