Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3515133..3515753 Replicon chromosome
Accession NZ_CP113536
Organism Salmonella enterica strain ZCX

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OXV07_RS17355 Protein ID WP_001280991.1
Coordinates 3515535..3515753 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OXV07_RS17350 Protein ID WP_000344807.1
Coordinates 3515133..3515507 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV07_RS17340 (3510272) 3510272..3511465 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OXV07_RS17345 (3511488) 3511488..3514637 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
OXV07_RS17350 (3515133) 3515133..3515507 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OXV07_RS17355 (3515535) 3515535..3515753 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OXV07_RS17360 (3515932) 3515932..3516483 + 552 WP_001278792.1 maltose O-acetyltransferase -
OXV07_RS17365 (3516600) 3516600..3517070 + 471 WP_000136181.1 YlaC family protein -
OXV07_RS17370 (3517126) 3517126..3517266 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OXV07_RS17375 (3517272) 3517272..3517532 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OXV07_RS17380 (3517757) 3517757..3519307 + 1551 WP_241594876.1 EAL domain-containing protein -
OXV07_RS17390 (3519538) 3519538..3519927 + 390 WP_000961285.1 MGMT family protein -
OXV07_RS17395 (3519960) 3519960..3520529 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T265927 WP_001280991.1 NZ_CP113536:3515535-3515753 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT265927 WP_000344807.1 NZ_CP113536:3515133-3515507 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References