265922

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2350606..2351128 Replicon chromosome
Accession NZ_CP113536
Organism Salmonella enterica strain ZCX

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag OXV07_RS11550 Protein ID WP_000221343.1
Coordinates 2350606..2350890 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag OXV07_RS11555 Protein ID WP_000885424.1
Coordinates 2350880..2351128 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV07_RS11530 (2346681) 2346681..2348189 - 1509 WP_023139072.1 FAD-dependent oxidoreductase -
OXV07_RS11535 (2348234) 2348234..2348722 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
OXV07_RS11540 (2348915) 2348915..2349994 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
OXV07_RS11545 (2350046) 2350046..2350435 - 390 WP_000194089.1 RidA family protein -
OXV07_RS11550 (2350606) 2350606..2350890 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OXV07_RS11555 (2350880) 2350880..2351128 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OXV07_RS11560 (2351280) 2351280..2351495 + 216 WP_000206207.1 hypothetical protein -
OXV07_RS11565 (2351485) 2351485..2351817 + 333 WP_000253154.1 DUF1493 family protein -
OXV07_RS11570 (2351960) 2351960..2352868 + 909 WP_010989018.1 hypothetical protein -
OXV07_RS11575 (2352924) 2352924..2353638 - 715 Protein_2267 helix-turn-helix domain-containing protein -
OXV07_RS11580 (2354446) 2354446..2355912 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T265922 WP_000221343.1 NZ_CP113536:c2350890-2350606 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT265922 WP_000885424.1 NZ_CP113536:c2351128-2350880 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References