Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4414296..4415077 Replicon chromosome
Accession NZ_CP113535
Organism Salmonella enterica strain ZLQ

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag OXV11_RS21730 Protein ID WP_000626099.1
Coordinates 4414296..4414787 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag OXV11_RS21735 Protein ID WP_001110452.1
Coordinates 4414784..4415077 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV11_RS21695 (4410291) 4410291..4410866 + 576 WP_001188509.1 transcriptional regulator -
OXV11_RS21705 (4411137) 4411137..4411214 - 78 Protein_4247 helix-turn-helix domain-containing protein -
OXV11_RS21710 (4411305) 4411305..4411637 - 333 WP_001165471.1 MerR family transcriptional regulator -
OXV11_RS21715 (4411709) 4411709..4412086 + 378 WP_000916345.1 EthD family reductase -
OXV11_RS21720 (4413119) 4413119..4413193 + 75 Protein_4250 porin family protein -
OXV11_RS21725 (4413296) 4413296..4414048 + 753 WP_000842434.1 non-specific acid phosphatase -
OXV11_RS21730 (4414296) 4414296..4414787 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
OXV11_RS21735 (4414784) 4414784..4415077 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
OXV11_RS21740 (4415394) 4415394..4415615 + 222 WP_001576552.1 hypothetical protein -
OXV11_RS21745 (4415880) 4415880..4416755 + 876 WP_000921674.1 AraC family transcriptional regulator -
OXV11_RS21750 (4416752) 4416752..4417039 + 288 WP_001269916.1 transcriptional regulator RtsB -
OXV11_RS21755 (4417062) 4417062..4417277 + 216 WP_001595136.1 hypothetical protein -
OXV11_RS21760 (4417285) 4417285..4417554 + 270 WP_010989096.1 hypothetical protein -
OXV11_RS21765 (4417848) 4417848..4418753 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T265913 WP_000626099.1 NZ_CP113535:c4414787-4414296 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT265913 WP_001110452.1 NZ_CP113535:c4415077-4414784 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References