Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 870033..870510 Replicon chromosome
Accession NC_017337
Organism Staphylococcus aureus subsp. aureus ED133

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAOV_RS04295 Protein ID WP_000052076.1
Coordinates 870033..870221 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAOV_RS04300 Protein ID WP_001059690.1
Coordinates 870250..870510 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAOV_RS04265 866020..866541 + 522 WP_000824478.1 hypothetical protein -
SAOV_RS04270 866882..867568 + 687 WP_001641381.1 thermonuclease family protein -
SAOV_RS04275 867925..868125 + 201 WP_001059082.1 cold-shock protein -
SAOV_RS04280 868624..868842 - 219 WP_000005880.1 hypothetical protein -
SAOV_RS04285 868904..869188 - 285 WP_001004402.1 hypothetical protein -
SAOV_RS04290 869276..869845 - 570 WP_001106650.1 hypothetical protein -
SAOV_RS04295 870033..870221 - 189 WP_000052076.1 hypothetical protein Toxin
SAOV_RS04300 870250..870510 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAOV_RS04305 870851..871054 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAOV_RS04310 871051..871287 - 237 WP_000368687.1 hypothetical protein -
SAOV_RS04315 871512..872093 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
SAOV_RS04320 872166..872783 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
SAOV_RS04325 872939..873433 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SAOV_RS04330 873832..874254 - 423 WP_000974462.1 organic hydroperoxide resistance protein -
SAOV_RS04335 874402..875118 + 717 WP_000150023.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T26591 WP_000052076.1 NC_017337:c870221-870033 [Staphylococcus aureus subsp. aureus ED133]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T26591 NC_017337:c870221-870033 [Staphylococcus aureus subsp. aureus ED133]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT26591 WP_001059690.1 NC_017337:c870510-870250 [Staphylococcus aureus subsp. aureus ED133]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT26591 NC_017337:c870510-870250 [Staphylococcus aureus subsp. aureus ED133]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References