Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4032561..4033077 Replicon chromosome
Accession NZ_CP113534
Organism Salmonella enterica strain ZYX

Toxin (Protein)


Gene name relE Uniprot ID A0A5I6CHB9
Locus tag OXV08_RS19490 Protein ID WP_000220581.1
Coordinates 4032561..4032845 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag OXV08_RS19495 Protein ID WP_000212724.1
Coordinates 4032835..4033077 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV08_RS19475 (4027677) 4027677..4029329 + 1653 WP_080197320.1 alpha,alpha-phosphotrehalase -
OXV08_RS19480 (4029738) 4029738..4031876 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
OXV08_RS19485 (4032093) 4032093..4032557 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OXV08_RS19490 (4032561) 4032561..4032845 - 285 WP_000220581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OXV08_RS19495 (4032835) 4032835..4033077 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OXV08_RS19500 (4033155) 4033155..4035068 - 1914 WP_139782548.1 BglG family transcription antiterminator -
OXV08_RS19505 (4035085) 4035085..4035825 - 741 WP_000779247.1 KDGP aldolase family protein -
OXV08_RS19510 (4035822) 4035822..4036940 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
OXV08_RS19515 (4036924) 4036924..4038057 - 1134 WP_079986648.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T265894 WP_000220581.1 NZ_CP113534:c4032845-4032561 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT265894 WP_000212724.1 NZ_CP113534:c4033077-4032835 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References