Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3947375..3947951 Replicon chromosome
Accession NZ_CP113534
Organism Salmonella enterica strain ZYX

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag OXV08_RS19085 Protein ID WP_001131963.1
Coordinates 3947664..3947951 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag OXV08_RS19080 Protein ID WP_000063143.1
Coordinates 3947375..3947677 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV08_RS19065 (3943885) 3943885..3946035 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
OXV08_RS19070 (3946130) 3946130..3946333 + 204 WP_000460616.1 YbdD/YjiX family protein -
OXV08_RS19075 (3946344) 3946344..3947300 + 957 WP_000612222.1 GTPase -
OXV08_RS19080 (3947375) 3947375..3947677 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
OXV08_RS19085 (3947664) 3947664..3947951 - 288 WP_001131963.1 BrnT family toxin Toxin
OXV08_RS19090 (3948220) 3948220..3949134 - 915 WP_000290515.1 restriction endonuclease -
OXV08_RS19095 (3949332) 3949332..3952841 + 3510 WP_080197506.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T265893 WP_001131963.1 NZ_CP113534:c3947951-3947664 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT265893 WP_000063143.1 NZ_CP113534:c3947677-3947375 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References