Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3350579..3351199 Replicon chromosome
Accession NZ_CP113534
Organism Salmonella enterica strain ZYX

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OXV08_RS16260 Protein ID WP_001280991.1
Coordinates 3350981..3351199 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OXV08_RS16255 Protein ID WP_000344807.1
Coordinates 3350579..3350953 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV08_RS16245 (3345718) 3345718..3346911 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OXV08_RS16250 (3346934) 3346934..3350083 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
OXV08_RS16255 (3350579) 3350579..3350953 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OXV08_RS16260 (3350981) 3350981..3351199 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OXV08_RS16265 (3351378) 3351378..3351929 + 552 WP_080197358.1 maltose O-acetyltransferase -
OXV08_RS16270 (3352046) 3352046..3352516 + 471 WP_000136183.1 YlaC family protein -
OXV08_RS16275 (3352572) 3352572..3352712 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OXV08_RS16280 (3352718) 3352718..3352978 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OXV08_RS16285 (3353203) 3353203..3354753 + 1551 WP_080197357.1 EAL domain-containing protein -
OXV08_RS16295 (3354984) 3354984..3355373 + 390 WP_000961285.1 MGMT family protein -
OXV08_RS16300 (3355406) 3355406..3355975 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T265890 WP_001280991.1 NZ_CP113534:3350981-3351199 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT265890 WP_000344807.1 NZ_CP113534:3350579-3350953 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References