Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2297222..2297744 Replicon chromosome
Accession NZ_CP113534
Organism Salmonella enterica strain ZYX

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag OXV08_RS11015 Protein ID WP_000221343.1
Coordinates 2297460..2297744 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag OXV08_RS11010 Protein ID WP_000885424.1
Coordinates 2297222..2297470 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV08_RS10985 (2293621) 2293621..2293743 - 123 WP_001176644.1 LysR family transcriptional regulator -
OXV08_RS10990 (2294554) 2294554..2295289 + 736 Protein_2148 helix-turn-helix domain-containing protein -
OXV08_RS10995 (2295345) 2295345..2296253 - 909 WP_079927926.1 hypothetical protein -
OXV08_RS11000 (2296533) 2296533..2296865 - 333 WP_000253154.1 DUF1493 family protein -
OXV08_RS11005 (2296855) 2296855..2297070 - 216 WP_000206207.1 hypothetical protein -
OXV08_RS11010 (2297222) 2297222..2297470 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OXV08_RS11015 (2297460) 2297460..2297744 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OXV08_RS11020 (2297915) 2297915..2298304 + 390 WP_000194089.1 RidA family protein -
OXV08_RS11025 (2298356) 2298356..2299435 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
OXV08_RS11030 (2299628) 2299628..2300116 - 489 WP_001293637.1 MarR family winged helix-turn-helix transcriptional regulator -
OXV08_RS11035 (2300161) 2300161..2301504 + 1344 Protein_2157 FAD-dependent oxidoreductase -
OXV08_RS11040 (2301494) 2301494..2302735 + 1242 WP_080196988.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2292034..2304361 12327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T265889 WP_000221343.1 NZ_CP113534:2297460-2297744 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT265889 WP_000885424.1 NZ_CP113534:2297222-2297470 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References