Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 840596..841221 Replicon chromosome
Accession NZ_CP113534
Organism Salmonella enterica strain ZYX

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OXV08_RS04050 Protein ID WP_000911337.1
Coordinates 840823..841221 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag OXV08_RS04045 Protein ID WP_000557545.1
Coordinates 840596..840823 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV08_RS04015 (835609) 835609..837126 + 1518 WP_000003339.1 lysine--tRNA ligase -
OXV08_RS04020 (837202) 837202..837747 - 546 WP_268653125.1 isopentenyl-diphosphate Delta-isomerase -
OXV08_RS04025 (838012) 838012..838770 + 759 WP_000244328.1 amidase activator ActS -
OXV08_RS04035 (839055) 839055..839861 - 807 WP_010989071.1 DUF1460 domain-containing protein -
OXV08_RS04040 (840136) 840136..840387 - 252 WP_001540858.1 hypothetical protein -
OXV08_RS04045 (840596) 840596..840823 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
OXV08_RS04050 (840823) 840823..841221 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
OXV08_RS04055 (842028) 842028..842564 + 537 WP_001038502.1 STM3031 family outer membrane protein -
OXV08_RS04060 (842611) 842611..843243 + 633 WP_000835265.1 YfdX family protein -
OXV08_RS04065 (843962) 843962..844543 + 582 WP_001244652.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 840136..850367 10231


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T265883 WP_000911337.1 NZ_CP113534:840823-841221 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT265883 WP_000557545.1 NZ_CP113534:840596-840823 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References