Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 200655..201415 Replicon chromosome
Accession NZ_CP113534
Organism Salmonella enterica strain ZYX

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag OXV08_RS00940 Protein ID WP_000533909.1
Coordinates 200930..201415 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag OXV08_RS00935 Protein ID WP_000965886.1
Coordinates 200655..200942 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV08_RS00915 (196060) 196060..196971 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
OXV08_RS00920 (196981) 196981..199050 + 2070 WP_020437730.1 glycine--tRNA ligase subunit beta -
OXV08_RS00925 (199440) 199440..199838 + 399 Protein_183 IS3 family transposase -
OXV08_RS00930 (200010) 200010..200477 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
OXV08_RS00935 (200655) 200655..200942 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
OXV08_RS00940 (200930) 200930..201415 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
OXV08_RS00945 (201787) 201787..202326 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
OXV08_RS00950 (202500) 202500..202712 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
OXV08_RS00955 (203000) 203000..203290 - 291 WP_000455790.1 HTH-type transcriptional regulator -
OXV08_RS00960 (203729) 203729..204439 + 711 WP_000190524.1 DUF3053 domain-containing protein -
OXV08_RS00965 (204489) 204489..205463 - 975 WP_023198076.1 glyoxylate/hydroxypyruvate reductase GhrB -
OXV08_RS00970 (205682) 205682..206344 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T265880 WP_000533909.1 NZ_CP113534:200930-201415 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T265880 NZ_CP113534:200930-201415 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT265880 WP_000965886.1 NZ_CP113534:200655-200942 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT265880 NZ_CP113534:200655-200942 [Salmonella enterica]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References