Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5462790..5463447 Replicon chromosome
Accession NZ_CP113529
Organism Mycobacterium sp. Aquia_216

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag OK015_RS25455 Protein ID WP_268127285.1
Coordinates 5462790..5463263 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag OK015_RS25460 Protein ID WP_268127286.1
Coordinates 5463268..5463447 (-) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK015_RS25430 (OK015_25430) 5458765..5459991 + 1227 WP_268127278.1 acetyl-CoA acetyltransferase -
OK015_RS25435 (OK015_25435) 5459993..5461504 + 1512 WP_268127280.1 carotenoid oxygenase family protein -
OK015_RS25440 (OK015_25440) 5461542..5462027 + 486 WP_268127282.1 VOC family protein -
OK015_RS25445 (OK015_25445) 5462032..5462466 - 435 WP_268127284.1 hypothetical protein -
OK015_RS25450 (OK015_25450) 5462563..5462733 - 171 Protein_5042 VOC family protein -
OK015_RS25455 (OK015_25455) 5462790..5463263 - 474 WP_268127285.1 SRPBCC family protein Toxin
OK015_RS25460 (OK015_25460) 5463268..5463447 - 180 WP_268127286.1 antitoxin Antitoxin
OK015_RS25465 (OK015_25465) 5463542..5465944 - 2403 WP_268127288.1 cation-translocating P-type ATPase -
OK015_RS25470 (OK015_25470) 5465941..5467533 - 1593 WP_268127291.1 serine hydrolase -
OK015_RS25475 (OK015_25475) 5467657..5468190 + 534 WP_268127293.1 G/U mismatch-specific DNA glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17080.81 Da        Isoelectric Point: 10.1618

>T265876 WP_268127285.1 NZ_CP113529:c5463263-5462790 [Mycobacterium sp. Aquia_216]
MAKLSGSIEVPLPPEQAWKHASDLSRFKDWLSIHRVWRSKLPDDLHKGTVIESVVEVKGMLNRIKWTIVHYKPPEAMTLN
GDGVGGVKVKLIAKVKPKDDGSVVSFDVHLGGPALFGPIGMIVAAALRSDINESLERFVTVFTAPDPGRNGHSGVGR

Download         Length: 474 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6422.14 Da        Isoelectric Point: 4.6881

>AT265876 WP_268127286.1 NZ_CP113529:c5463447-5463268 [Mycobacterium sp. Aquia_216]
MGFLDKAKDLLAQNADKVETAIDKAGEFVDDKTQGKYSDTIHKVQEEAKKAVDPGTPQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References