Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2316102..2316688 Replicon chromosome
Accession NZ_CP113517
Organism Methylomonas rapida strain MP1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NM686_RS10960 Protein ID WP_255187905.1
Coordinates 2316434..2316688 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NM686_RS10955 Protein ID WP_255187904.1
Coordinates 2316102..2316437 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM686_RS10930 (NM686_010930) 2311732..2312370 + 639 WP_255187900.1 hypothetical protein -
NM686_RS10935 (NM686_010935) 2312441..2313220 + 780 WP_255187901.1 DUF2939 domain-containing protein -
NM686_RS10940 (NM686_010940) 2313480..2314280 + 801 WP_255187902.1 phage antirepressor N-terminal domain-containing protein -
NM686_RS10945 (NM686_010945) 2314320..2314499 + 180 WP_255187903.1 hypothetical protein -
NM686_RS10950 (NM686_010950) 2314537..2315922 - 1386 WP_255187523.1 IS4 family transposase -
NM686_RS10955 (NM686_010955) 2316102..2316437 - 336 WP_255187904.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NM686_RS10960 (NM686_010960) 2316434..2316688 - 255 WP_255187905.1 type II toxin-antitoxin system HicA family toxin Toxin
NM686_RS10965 (NM686_010965) 2316929..2317141 + 213 WP_255187906.1 hypothetical protein -
NM686_RS10970 (NM686_010970) 2317138..2318748 + 1611 WP_255187907.1 phage portal protein -
NM686_RS10975 (NM686_010975) 2318754..2319104 + 351 WP_255187908.1 hypothetical protein -
NM686_RS10980 (NM686_010980) 2319109..2320380 + 1272 WP_255187909.1 S49 family peptidase -
NM686_RS10985 (NM686_010985) 2320380..2321234 + 855 WP_255187910.1 head decoration protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2314537..2315922 1385


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9432.85 Da        Isoelectric Point: 10.5958

>T265866 WP_255187905.1 NZ_CP113517:c2316688-2316434 [Methylomonas rapida]
MKRKHQKTIEALFAHPVGANIPWRDIESLFLELGATVSEREGSRVCVVLFGQVRVFHRPHPSPNTDKGAVASVRDWLKSH
GVHP

Download         Length: 255 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 11929.57 Da        Isoelectric Point: 4.6127

>AT265866 WP_255187904.1 NZ_CP113517:c2316437-2316102 [Methylomonas rapida]
MINQMMIAGVKAVITYDSDLELFRGEFVGLSGSADFYAADVAGLKREGEISLRVYLEACQESGIEPFKAFSGKFNVRIPA
DLHASIVSAAAAQGKSINQWIGEALSREVNA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References