Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2276856..2277520 Replicon chromosome
Accession NZ_CP113517
Organism Methylomonas rapida strain MP1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NM686_RS10755 Protein ID WP_255187871.1
Coordinates 2277092..2277520 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NM686_RS10750 Protein ID WP_255187870.1
Coordinates 2276856..2277095 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM686_RS10725 (NM686_010725) 2271940..2272221 + 282 WP_255187866.1 Mor transcription activator family protein -
NM686_RS10730 (NM686_010730) 2272279..2272590 - 312 WP_255187867.1 helix-turn-helix domain-containing protein -
NM686_RS10735 (NM686_010735) 2272592..2272879 - 288 WP_269022874.1 transcriptional regulator -
NM686_RS10740 (NM686_010740) 2273049..2276060 - 3012 WP_255187869.1 Tn3 family transposase -
NM686_RS10745 (NM686_010745) 2276077..2276655 - 579 WP_255188597.1 recombinase family protein -
NM686_RS10750 (NM686_010750) 2276856..2277095 + 240 WP_255187870.1 hypothetical protein Antitoxin
NM686_RS10755 (NM686_010755) 2277092..2277520 + 429 WP_255187871.1 type II toxin-antitoxin system VapC family toxin Toxin
NM686_RS10760 (NM686_010760) 2277819..2279729 - 1911 Protein_2132 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2232653..2284763 52110
- inside IScluster/Tn - - 2276077..2279741 3664


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15451.79 Da        Isoelectric Point: 5.1356

>T265865 WP_255187871.1 NZ_CP113517:2277092-2277520 [Methylomonas rapida]
MILLDTNVVSEPLKASCDKSVLSWIDEQVIETLYLSTISLAELRFGIAVLPEGKRRDTLFSSLEQQVLPLFAGRILLFDE
SASQAYATLRARARTAGQAIATADGYIAAIAVAHGFAVATRDTSPFEAVGLKVINPWTWMAH

Download         Length: 429 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8732.89 Da        Isoelectric Point: 5.6158

>AT265865 WP_255187870.1 NZ_CP113517:2276856-2277095 [Methylomonas rapida]
MASVTVRNLSDETHRALRVRAAMHGHSTEAEIRAILDNTVRPDNRIKLGSLLAKIGLEVGGVDLEIERDKSPTEPLDFE

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References