Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 568831..569467 Replicon chromosome
Accession NZ_CP113516
Organism Bacillus paralicheniformis strain 285-3

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag OU809_RS02835 Protein ID WP_003179128.1
Coordinates 569117..569467 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag OU809_RS02830 Protein ID WP_006638778.1
Coordinates 568831..569112 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU809_RS02810 (OU809_02810) 563942..565426 + 1485 WP_103750290.1 PH domain-containing protein -
OU809_RS02815 (OU809_02815) 565423..566022 - 600 WP_023857867.1 rhomboid family intramembrane serine protease -
OU809_RS02820 (OU809_02820) 566366..567325 + 960 WP_164468292.1 outer membrane lipoprotein carrier protein LolA -
OU809_RS02825 (OU809_02825) 567550..568719 + 1170 WP_186442187.1 alanine racemase -
OU809_RS02830 (OU809_02830) 568831..569112 + 282 WP_006638778.1 hypothetical protein Antitoxin
OU809_RS02835 (OU809_02835) 569117..569467 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
OU809_RS02840 (OU809_02840) 569585..570412 + 828 WP_023857863.1 RsbT co-antagonist protein RsbRA -
OU809_RS02845 (OU809_02845) 570416..570781 + 366 WP_031305225.1 STAS domain-containing protein -
OU809_RS02850 (OU809_02850) 570784..571185 + 402 WP_023857861.1 anti-sigma regulatory factor -
OU809_RS02855 (OU809_02855) 571196..572203 + 1008 WP_020450261.1 PP2C family protein-serine/threonine phosphatase -
OU809_RS02860 (OU809_02860) 572262..572588 + 327 WP_020450262.1 anti-sigma factor antagonist -
OU809_RS02865 (OU809_02865) 572588..573070 + 483 WP_020450263.1 anti-sigma B factor RsbW -
OU809_RS02870 (OU809_02870) 573036..573827 + 792 WP_023857858.1 RNA polymerase sigma factor SigB -
OU809_RS02875 (OU809_02875) 573824..574423 + 600 WP_023857857.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T265860 WP_003179128.1 NZ_CP113516:569117-569467 [Bacillus paralicheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT265860 WP_006638778.1 NZ_CP113516:568831-569112 [Bacillus paralicheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References