Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3996361..3997001 Replicon chromosome
Accession NZ_CP113504
Organism Pectobacterium brasiliense strain 21PCA_AGRO2

Toxin (Protein)


Gene name vagD Uniprot ID A0A7V8Q162
Locus tag OWC53_RS18355 Protein ID WP_039278477.1
Coordinates 3996361..3996777 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A086EF97
Locus tag OWC53_RS18360 Protein ID WP_039278475.1
Coordinates 3996774..3997001 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWC53_RS18335 (OWC53_18320) 3991946..3992932 - 987 WP_039465906.1 quinone oxidoreductase -
OWC53_RS18340 (OWC53_18325) 3993060..3994466 + 1407 WP_010279223.1 replicative DNA helicase -
OWC53_RS18345 (OWC53_18330) 3994508..3995590 + 1083 WP_075278336.1 alanine racemase -
OWC53_RS18350 (OWC53_18335) 3995583..3996221 + 639 WP_039517591.1 hypothetical protein -
OWC53_RS18355 (OWC53_18340) 3996361..3996777 - 417 WP_039278477.1 type II toxin-antitoxin system VapC family toxin Toxin
OWC53_RS18360 (OWC53_18345) 3996774..3997001 - 228 WP_039278475.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OWC53_RS18365 (OWC53_18350) 3997794..3998273 + 480 WP_010295086.1 Lrp/AsnC family transcriptional regulator -
OWC53_RS18370 (OWC53_18355) 3998524..3999138 + 615 WP_010279239.1 YitT family protein -
OWC53_RS18375 (OWC53_18360) 3999202..4000395 + 1194 WP_268197755.1 amino acid aminotransferase -
OWC53_RS18380 (OWC53_18365) 4000479..4000976 + 498 WP_052902928.1 M48 family metallopeptidase -
OWC53_RS18385 (OWC53_18370) 4001358..4001594 + 237 Protein_3589 type VI secretion system tube protein TssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15274.80 Da        Isoelectric Point: 8.2931

>T265854 WP_039278477.1 NZ_CP113504:c3996777-3996361 [Pectobacterium brasiliense]
VSRLFMLDTNICSFIMREHPAEVIEKLQQCTLRRDRIVVSAITYAEMRFGAVGKKASPRHMQLVDAFCRRLDAVLPWDSA
AVDATTKIKIELAAAGTPIGPNDTAIAGHAISAKAILVTNNLREFERVPGLTLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8879.08 Da        Isoelectric Point: 4.8359

>AT265854 WP_039278475.1 NZ_CP113504:c3997001-3996774 [Pectobacterium brasiliense]
MRIVSVFKNGNNRAIRLPRDMDFEGVNELEIVREGDTIMLRPVKPNWHSFLQEDRADADFMTERQDVVEEGRFKL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8Q162

Antitoxin

Source ID Structure
AlphaFold DB A0A086EF97

References