Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1259468..1260093 Replicon chromosome
Accession NZ_CP113504
Organism Pectobacterium brasiliense strain 21PCA_AGRO2

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag OWC53_RS05800 Protein ID WP_005976087.1
Coordinates 1259468..1259671 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag OWC53_RS05805 Protein ID WP_010282247.1
Coordinates 1259725..1260093 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWC53_RS05770 (OWC53_05765) 1254801..1255139 + 339 WP_002208627.1 P-II family nitrogen regulator -
OWC53_RS05775 (OWC53_05770) 1255179..1256465 + 1287 WP_014914537.1 ammonium transporter AmtB -
OWC53_RS05780 (OWC53_05775) 1256606..1257469 - 864 WP_014914538.1 acyl-CoA thioesterase II -
OWC53_RS05785 (OWC53_05780) 1257682..1258263 + 582 WP_014914539.1 YbaY family lipoprotein -
OWC53_RS05790 (OWC53_05785) 1258283..1258603 - 321 WP_010282239.1 MGMT family protein -
OWC53_RS05800 (OWC53_05795) 1259468..1259671 - 204 WP_005976087.1 HHA domain-containing protein Toxin
OWC53_RS05805 (OWC53_05800) 1259725..1260093 - 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
OWC53_RS05810 (OWC53_05805) 1260693..1260836 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
OWC53_RS05815 (OWC53_05810) 1260854..1261102 - 249 WP_014914542.1 type B 50S ribosomal protein L31 -
OWC53_RS05820 (OWC53_05815) 1261335..1264463 - 3129 WP_205546137.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T265851 WP_005976087.1 NZ_CP113504:c1259671-1259468 [Pectobacterium brasiliense]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT265851 WP_010282247.1 NZ_CP113504:c1260093-1259725 [Pectobacterium brasiliense]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References