265844

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 518003..519647 Replicon chromosome
Accession NZ_CP113504
Organism Pectobacterium brasiliense strain 21PCA_AGRO2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OWC53_RS02440 Protein ID WP_268198163.1
Coordinates 518313..519647 (+) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OWC53_RS02435 Protein ID WP_268198162.1
Coordinates 518003..518308 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWC53_RS02395 (OWC53_02390) 513065..513538 + 474 WP_268198153.1 DNA repair protein RadC -
OWC53_RS02400 (OWC53_02395) 513578..513913 + 336 WP_268198155.1 type IV toxin-antitoxin system YeeU family antitoxin -
OWC53_RS02405 (OWC53_02400) 513982..514302 + 321 WP_268198156.1 TA system toxin CbtA family protein -
OWC53_RS02410 (OWC53_02405) 514420..515199 + 780 WP_268198158.1 DUF4942 domain-containing protein -
OWC53_RS02415 (OWC53_02410) 515360..515608 + 249 WP_268198159.1 ribbon-helix-helix domain-containing protein -
OWC53_RS02420 (OWC53_02415) 515612..515887 + 276 WP_039517502.1 type II toxin-antitoxin system RelE/ParE family toxin -
OWC53_RS02425 (OWC53_02420) 515935..516447 + 513 WP_268198161.1 AAA family ATPase -
OWC53_RS02430 (OWC53_02425) 516966..517778 + 813 Protein_470 integrase arm-type DNA-binding domain-containing protein -
OWC53_RS02435 (OWC53_02430) 518003..518308 + 306 WP_268198162.1 helix-turn-helix transcriptional regulator Antitoxin
OWC53_RS02440 (OWC53_02435) 518313..519647 + 1335 WP_268198163.1 type II toxin-antitoxin system HipA family toxin Toxin
OWC53_RS02445 (OWC53_02440) 519713..520006 - 294 WP_268198164.1 AAA family ATPase -
OWC53_RS02450 (OWC53_02445) 520174..520593 + 420 WP_268198165.1 GNAT family N-acetyltransferase -
OWC53_RS02455 (OWC53_02450) 520693..521814 + 1122 WP_268198166.1 cupin domain-containing protein -
OWC53_RS02460 (OWC53_02455) 521991..523150 + 1160 Protein_476 lipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 50754.86 Da        Isoelectric Point: 6.1417

>T265844 WP_268198163.1 NZ_CP113504:518313-519647 [Pectobacterium brasiliense]
MPRTQQRLAIWMNGIQVGFWEKTRGEDRLQYLPEWIADEQGRPLSLSLLFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
ATRYHADSLEPFDLLAELGRDCVGAIQLLNGNEEPTDLFSVKYRPLCDAEIAAILRNTTAALLPGRQDDTDDLRLSIAGA
QEKTALLWHEGQWCLPEGSTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLILKEYGIPVAKTQIAQFEEQKALVVERF
DRRWSSDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMTILSHSEQAEQDKAQFFRAQIIFWLIAATDGHAKNFS
IAIEPQGRYHLTPLYDVLSAWPVIGPHNNQISWQKCKLAMAVRGSSNYYHLYRIKRRHWVNHGELTGLGRRQVEAIMDDI
ISRTPEVIERVSSLLPEPFPPELAECVFDGMRQQCGRLQELHRK

Download         Length: 1335 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11233.96 Da        Isoelectric Point: 10.3119

>AT265844 WP_268198162.1 NZ_CP113504:518003-518308 [Pectobacterium brasiliense]
MNTVYSLKTLNQLRPLLIGFRKAKGLTQKDVSERLGVTQQTYARLEASPGSASIERLFKVLTVLGVEVVLSSGPNVHFSM
SSSTMEEPEKPIDSPARREKW

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References