Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4652381..4652878 Replicon chromosome
Accession NZ_CP113503
Organism Escherichia coli strain 16843

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag OWO50_RS22360 Protein ID WP_001173343.1
Coordinates 4652381..4652554 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag OWO50_RS22365 Protein ID WP_001312331.1
Coordinates 4652582..4652878 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWO50_RS22350 (4649051) 4649051..4650508 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
OWO50_RS22355 (4650745) 4650745..4652262 + 1518 WP_000003805.1 lysine--tRNA ligase -
OWO50_RS22360 (4652381) 4652381..4652554 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
OWO50_RS22365 (4652582) 4652582..4652878 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
OWO50_RS22370 (4653107) 4653107..4653379 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
OWO50_RS22375 (4653391) 4653391..4653621 - 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
OWO50_RS22380 (4653802) 4653802..4655433 + 1632 WP_001216466.1 sensor histidine kinase -
OWO50_RS22385 (4655430) 4655430..4656149 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4629586..4652878 23292


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T265838 WP_001173343.1 NZ_CP113503:c4652554-4652381 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT265838 WP_001312331.1 NZ_CP113503:c4652878-4652582 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References