Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3601528..3602146 Replicon chromosome
Accession NZ_CP113503
Organism Escherichia coli strain 16843

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag OWO50_RS17315 Protein ID WP_001291435.1
Coordinates 3601928..3602146 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OWO50_RS17310 Protein ID WP_000344800.1
Coordinates 3601528..3601902 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWO50_RS17300 (3596617) 3596617..3597810 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OWO50_RS17305 (3597833) 3597833..3600983 + 3151 Protein_3395 efflux RND transporter permease AcrB -
OWO50_RS17310 (3601528) 3601528..3601902 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OWO50_RS17315 (3601928) 3601928..3602146 + 219 WP_001291435.1 HHA domain-containing protein Toxin
OWO50_RS17320 (3602320) 3602320..3602871 + 552 WP_000102539.1 maltose O-acetyltransferase -
OWO50_RS17325 (3602987) 3602987..3603457 + 471 WP_000136192.1 YlaC family protein -
OWO50_RS17330 (3603621) 3603621..3605171 + 1551 WP_001298569.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OWO50_RS17335 (3605213) 3605213..3605566 - 354 WP_000878138.1 DUF1428 family protein -
OWO50_RS17345 (3605945) 3605945..3606256 + 312 WP_000409908.1 MGMT family protein -
OWO50_RS17350 (3606287) 3606287..3606859 - 573 WP_000779830.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T265827 WP_001291435.1 NZ_CP113503:3601928-3602146 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT265827 WP_000344800.1 NZ_CP113503:3601528-3601902 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References