Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1024012..1024666 Replicon chromosome
Accession NZ_CP113503
Organism Escherichia coli strain 16843

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag OWO50_RS05025 Protein ID WP_000244765.1
Coordinates 1024259..1024666 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag OWO50_RS05020 Protein ID WP_000354046.1
Coordinates 1024012..1024278 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWO50_RS05000 (1020100) 1020100..1021533 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
OWO50_RS05005 (1021578) 1021578..1021889 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
OWO50_RS05010 (1022053) 1022053..1022712 + 660 WP_000250274.1 hemolysin III family protein -
OWO50_RS05015 (1022789) 1022789..1023769 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
OWO50_RS05020 (1024012) 1024012..1024278 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
OWO50_RS05025 (1024259) 1024259..1024666 + 408 WP_000244765.1 protein YgfX Toxin
OWO50_RS05030 (1024706) 1024706..1025227 - 522 WP_001055874.1 flavodoxin FldB -
OWO50_RS05035 (1025339) 1025339..1026235 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OWO50_RS05040 (1026260) 1026260..1026970 + 711 WP_000715229.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OWO50_RS05045 (1026976) 1026976..1028709 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T265816 WP_000244765.1 NZ_CP113503:1024259-1024666 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT265816 WP_000354046.1 NZ_CP113503:1024012-1024278 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References