Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4505948..4506602 Replicon chromosome
Accession NZ_CP113493
Organism Escherichia coli strain GTEN_97

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag E5R32_RS21785 Protein ID WP_000244781.1
Coordinates 4505948..4506355 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag E5R32_RS21790 Protein ID WP_001564007.1
Coordinates 4506336..4506602 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5R32_RS21765 (4501905) 4501905..4503638 - 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -
E5R32_RS21770 (4503644) 4503644..4504354 - 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
E5R32_RS21775 (4504379) 4504379..4505275 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
E5R32_RS21780 (4505387) 4505387..4505908 + 522 WP_001055874.1 flavodoxin FldB -
E5R32_RS21785 (4505948) 4505948..4506355 - 408 WP_000244781.1 protein YgfX Toxin
E5R32_RS21790 (4506336) 4506336..4506602 - 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
E5R32_RS21795 (4506845) 4506845..4507825 + 981 WP_001564008.1 tRNA-modifying protein YgfZ -
E5R32_RS21800 (4507902) 4507902..4508561 - 660 WP_000250274.1 hemolysin III family protein -
E5R32_RS21805 (4508725) 4508725..4509036 - 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
E5R32_RS21810 (4509081) 4509081..4510514 + 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T265797 WP_000244781.1 NZ_CP113493:c4506355-4505948 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT265797 WP_001564007.1 NZ_CP113493:c4506602-4506336 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References