Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2857012..2857650 Replicon chromosome
Accession NZ_CP113493
Organism Escherichia coli strain GTEN_97

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag E5R32_RS13905 Protein ID WP_000813795.1
Coordinates 2857012..2857188 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E5R32_RS13910 Protein ID WP_076797675.1
Coordinates 2857234..2857650 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5R32_RS13885 (2852634) 2852634..2853806 - 1173 WP_001551088.1 BenE family transporter YdcO -
E5R32_RS13890 (2853898) 2853898..2854434 + 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
E5R32_RS13895 (2854507) 2854507..2856468 + 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
E5R32_RS13900 (2856560) 2856560..2856790 - 231 WP_023910283.1 YncJ family protein -
E5R32_RS13905 (2857012) 2857012..2857188 + 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
E5R32_RS13910 (2857234) 2857234..2857650 + 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
E5R32_RS13915 (2857729) 2857729..2859135 + 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
E5R32_RS13920 (2859380) 2859380..2860525 + 1146 WP_001551094.1 ABC transporter substrate-binding protein -
E5R32_RS13925 (2860543) 2860543..2861556 + 1014 WP_001551095.1 ABC transporter ATP-binding protein -
E5R32_RS13930 (2861557) 2861557..2862498 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T265789 WP_000813795.1 NZ_CP113493:2857012-2857188 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT265789 WP_076797675.1 NZ_CP113493:2857234-2857650 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References