Detailed information of TA system TA265784

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1565623..1567312
• Replicon: chromosome
• Accession: NZ_CP113493
• Organism: Escherichia coli strain GTEN_97

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: V0Z9M0
• Locus tag: E5R32_RS07650
• Protein ID: WP_000365809.1
• Coordinates: 1566392..1567312 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: E5R32_RS07645
• Protein ID: WP_001550661.1
• Coordinates: 1565623..1566405 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5R32_RS07625 (1560932)	1560932..1561090	-	159	Protein_1493	integrase	-
E5R32_RS07630 (1561182)	1561182..1561284	-	103	Protein_1494	helix-turn-helix domain-containing protein	-
E5R32_RS07635 (1561281)	1561281..1561751	-	471	WP_000201185.1	hypothetical protein	-
E5R32_RS07640 (1562098)	1562098..1565307	-	3210	WP_001521910.1	RNA-directed DNA polymerase	-
E5R32_RS07645 (1565623)	1565623..1566405	+	783	WP_001550661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
E5R32_RS07650 (1566392)	1566392..1567312	+	921	WP_000365809.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
E5R32_RS07655 (1567746)	1567746..1568630	-	885	WP_001119037.1	LysR family transcriptional regulator	-
E5R32_RS07660 (1568895)	1568895..1569953	+	1059	WP_122987197.1	alpha/beta hydrolase	-
E5R32_RS07665 (1570095)	1570095..1571222	+	1128	WP_001550663.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34571.01 Da
• Isoelectric Point: 7.2649

>T265784 WP_000365809.1 NZ_CP113493:1566392-1567312 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29191.43 Da
• Isoelectric Point: 8.9059

>AT265784 WP_001550661.1 NZ_CP113493:1565623-1566405 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: V0Z9M0