Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 56370..56995 Replicon plasmid unnamed1
Accession NZ_CP113487
Organism Escherichia coli strain GTEN_23

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FG550_RS25340 Protein ID WP_000911333.1
Coordinates 56597..56995 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag FG550_RS25335 Protein ID WP_000450520.1
Coordinates 56370..56597 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG550_RS25335 (56370) 56370..56597 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
FG550_RS25340 (56597) 56597..56995 + 399 WP_000911333.1 tRNA(fMet)-specific endonuclease VapC Toxin
FG550_RS25345 (57004) 57004..58008 - 1005 Protein_69 type IV secretion system DNA-binding domain-containing protein -
FG550_RS25350 (58116) 58116..58952 - 837 WP_000480972.1 aminoglycoside O-phosphotransferase APH(6)-Id -
FG550_RS25355 (58952) 58952..59755 - 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
FG550_RS25360 (59816) 59816..60631 - 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
FG550_RS25365 (60965) 60965..61168 + 204 WP_000131876.1 hypothetical protein -
FG550_RS25370 (61159) 61159..61380 + 222 WP_001251694.1 hypothetical protein -
FG550_RS25375 (61615) 61615..61974 - 360 WP_000050069.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B iutA / iucD / iucC / iucB / iucA 1..123389 123389
- flank IS/Tn aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B - 58116..63986 5870


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14919.19 Da        Isoelectric Point: 7.8605

>T265769 WP_000911333.1 NZ_CP113487:56597-56995 [Escherichia coli]
MLKFMLDTNICIFTMKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT265769 WP_000450520.1 NZ_CP113487:56370-56597 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References